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KMID : 0043320230460070646
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Archives of Pharmacal Research
2023 Volume.46 No. 7 p.646 ~ p.658
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Ionically bridged dexamethasone sodium phosphate?zinc?PLGA nanocomplex in alginate microgel for the local treatment of ulcerative colitis
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Aruzhan Saparbayeva
Lee Ju-Ho
Shwe Phyu Hlaing
Kim Ji-Hyun
Kwak Dong-Min
Kim Hyun-Woo
Lee Eun-Hee
Hwang Seong-Hwan
Kim Min-Soo
Moon Hyung-Ryong
Jung Yun-Jin
Yoo Jin-Wook
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Abstract
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Colon-targeted oral drug delivery systems comprising nanoparticles and microparticles have emerged as promising tools for the treatment of ulcerative colitis (UC) because they minimize side effects and maximize the local drug concentration. Dexamethasone sodium phosphate (DSP) is a potent anti-inflammatory glucocorticoid used for the treatment of UC. However, it remains a rather short-term treatment option owing to its side effects. In the present study, we developed the alginate gel encapsulating ionically bridged DSP-zinc-poly(lactic-co-glycolic acid) (PLGA) nanocomplex (DZP-NCs-in-microgel)? for the oral local treatment of UC. The successful encapsulation of DSP-zinc-PLGA nanocomplex (DZP-NCs) in alginate microgel was confirmed by SEM imaging. The prepared gel released DZP-NCs in the stimulated intestinal fluid and dampened the release of DSP in the upper gastrointestinal tract. Furthermore, DZP-NCs-in-microgel alleviated colonic inflammation in a mouse model of dextran sodium sulfate-induced colitis by relieving clinical symptoms and histological marks. Our results suggest a novel approach for the oral colon-targeted delivery of dexamethasone sodium phosphate for the treatment of UC.
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KEYWORD
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Ulcerative colitis, Dexamethasone, Nanoparticles, Drug delivery
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